Single-neuron projectome of mouse prefrontal cortex. Quantitative census of local somatic features in mouse visual cortex. Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells.
Phenotypic variation of transcriptomic cell types in mouse motor cortex. Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas. Classification of electrophysiological and morphological neuron types in the mouse visual cortex. Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex. Reconstruction and simulation of neocortical microcircuitry. NeuroMorpho.Org: a central resource for neuronal morphologies.
Neuronal cell-type classification: challenges, opportunities and the path forward. Together, our study provides a comprehensive structural repertoire for the reconstruction and analysis of PFC neural network. Finally, integrative dendrite–axon analysis uncovered the organization of potential intra-column, inter-hemispheric and inter-column connectivity among projection neuron types in PFC.
Furthermore, correspondence analysis among dendrites, local axons and long-range axons revealed coherent morphological changes associated with electrophysiological phenotypes. We uncovered 24 morphologically distinguishable dendrite subtypes in 1,515 pyramidal projection neurons and 405 atypical pyramidal projection neurons and spiny stellate neurons with unique axon projection patterns. We identified morphological variations of somata, dendrites and axons across laminar layers and PFC subregions and the general rules of somatodendritic scaling with cytoarchitecture. Here we report the complete dendrite and axon morphology of nearly 2,000 neurons in mouse prefrontal cortex (PFC). The structures of dendrites and axons form the basis for the connectivity of neural network, but their precise relationship at single-neuron level remains unclear.
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